Endometriumbiopsy / Scratching

Endometrial irritation is manipulation using a small catheter on the lining of the uterus. The catheter is inserted through the vagina via the cervix and into the uterine cavity.


For patients with unsuccessful implantation of the embryo, many investigations are carried out for clarification. The lining of the uterus is a key factor in implantation. Previous studies have shown that this type of scratching is helpful. We recommend this treatment after 2 unsuccessful treatment cycles (IVF, ICSI).

Mechanism of action:

This procedure has been used around the world for many years. The following mechanism is used as an explanation for the helpful mechanism of action:

1. Within the minimal wound that occurs in the uterine cavity on the mucosa, a healing process occurs, which is accompanied by an improvement in blood flow and mucosal quality in the following cycle.

2. As part of this wound healing, there is activation of certain genes in the uterine mucosa that are useful for embryonic implantation.


In the treatment cycle prior to IVF therapy or frozen egg implantation, this procedure should be performed on approximately the 21st day of the cycle. You should not be pregnant during this cycle to avoid procedures that would harm embryonic development. Accordingly, you should not have had unprotected sexual intercourse during this cycle. No special precautions are necessary on this day. You may have eaten normally before.

Procedure of the examination:

This is not a painful examination. Nevertheless, when inserting the catheter and manipulating the endometrium, you may feel discomfort (small stinging sensation in the abdomen).

First, a speculum examination is performed to view the cervix. The vagina and cervix are disinfected. Then a small catheter is inserted into the uterine cavity, irritating the lining of the uterus.

After the examination, there may be minimal bleeding. No other restraints are expected for that day. However, if needed, pain medications such as acetaminophen, Buscopan or Ibuprofen may be taken that day.


In addition to the spotting mentioned above, infections may also occur. However, the probability of this is minimal. However, if you experience fever, discharge, increasing lower abdominal pain or general malaise in the following days, we would ask you to contact us.

Success rates:

Studies to date, especially so-called meta-analyses (summary of many studies over several years) show an improvement in pregnancy rates of up to 10%.

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